technology
technology

Our Technology

Autophagy is one of the best studied phenomena of the cell. It is responsible for destroying proteins, mitochondria, and other cellular debris, and is one of the many natural defence systems against viruses and bacteria.

Automera exploits the general-purpose degradation abilities of autophagy to selectively destroy disease-causing targets. Because autophagy is a general-purpose degrader, our platform can degrade more than just proteins. It can target protein aggregates, dysfunctional mitochondria, viruses, bacteria, and other cellular organelles.

Automera has built a proprietary arsenal of autophagy warheads that bind to and activate autophagy. We are then able to attach any disease-targeting ligands to these warheads to induce degradation. These are known as autophagy-targeting chimeric molecules (AUTAC).

01

The disease-targeting ligand. This component selectively binds anywhere to a disease-causing target.

02

The autophagy warhead. This component brings the chimeric small molecule into the autophagy machinery and activates it.

03

The linker. This keeps the targeting ligand near the autophagy warhead, ensuring that the disease target is degraded when autophagy is activated.

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Advantages

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Our platform uses state-of-the-art computational chemistry, artificial intelligence, and quantum molecular dynamics to design chimeric small molecules that bind simultaneously to autophagy and the selected disease target.

01

Target proteins, large proteins, and protein aggregates

02

Target dysfunctional mitochondria

03

Target viruses and bacteria

04

Targets are degraded not just inhibited

05

Autophagy is iterative and has multiple mechanisms-of-action